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San Pedro y San Pablo de Patale
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| Location: | Leon County, Florida |
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| Nearest city: | Tallahassee |
| NRHP Reference#: | 72000336 |
| Added to NRHP: | June 26, 1972 |
San Pedro y San Pablo de Patale was a Spanish Franciscan mission built in the early 17th century in the Florida Panhandle, six miles east of Tallahassee, Florida. It was part of Spain's effort to colonize the region, and convert the Timucuan and Apalachee Indians to Christianity. The mission lasted until 1704, when it was captured by a militia of Creek Indians and South Carolinians.
The site where the mission stood was added to the U.S. National Register of Historic Places on June 26, 1972.